-
Use of Neuromodulation to Relieve Gait Freezing in Parkinson’s Disease
… episodes of freezing of gait, which is a sudden inability to take a step while walking. Gait freezing can cause falls … and possibly mortality, and it is associated with depression, social isolation and stigma. Current treatments … but do not treat gait freezing. In this study, we will test the accuracy of a new algorithm for detecting gait …
-
The Parkinson’s Minute: A Day in the Life with a Parkinson’s Disease Researcher
September 9, 2012
… and “Parkinson’s Minute” host Dave Iverson asks in the latest version of the video series. The Michael J. Fox Foundation (MJFF) is devoted to investing resources into addressing the critical unmet … Parkinson’s Institute in Sunnyvale, California, a facility where basic research, clinical studies and patient care all …
-
Possible Disease-Modifying Therapy for Parkinson’s One Step Closer to Patients
November 26, 2014
… A promising disease-modifying therapy is getting closer to reaching people with Parkinson’s. Isradipine — a medication currently approved to treat high blood pressure — is being studied to determine if it can influence … See if you are eligible for ongoing clinical trials by completing a profile on Fox Trial Finder . Watch the full …
-
Bitopertin to Alleviate Dyskinesia in Parkinson's Disease
… therapies for dyskinesia are only partly effective to alleviate the abnormal movements, and dyskinesia remains … administration. We will also investigate if the drug can prevent dyskinesia from appearing. Impact on … of our novel therapeutic paradigm. Following positive outcomes, we aim to further characterize the effect of our new …
-
‘Parkinson’s Isn’t Going to Get Me,’ Says Fox Trial Finder Ambassador Bob Harmon
December 20, 2012
… in 2006, 63-year-old Bob Harmon has “made it his job” to inform people about all that’s going on in PD research: … It’s not that they’re not willing, they just don’t know how, and where, to get started. But this past year, The Michael J. Fox …
-
Synthetic Nurr1 Ligands as Novel Neuroprotective Therapeutics to Treat Parkinson’s Disease
… Objective/Rationale: The orphan nuclear receptor Nurr1 plays a critical role in the development and … treatment of Parkinson’s disease (PD). Based on encouraging preliminary data from our laboratory, we propose to identify … effects. In support of our project, we identified three compounds with an identical chemical scaffold that activate …