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Validation of a Blood-based Gene Expression Assay for Early Diagnosis and Monitoring Disease
… disease (PD) is crucial for the early diagnosis of PD; monitoring PD severity/progression; and developing treatments … that can stop or slow PD progression. Our earlier study showed that the quantitative expression of a set of genes was altered in brains of PD patients compared to controls. Investigation of the most altered …
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Preclinical Testing of Novel DBS Protocol for Long-Lasting Therapeutic Effects
… Deep brain stimulation is an effective therapy for motor symptoms of late-stage Parkinson’s disease. It works … We hypothesize that the GPi is the optimal surgical target for our novel DBS protocol and that treatment epochs as … of DBS delivered to each target to provide a set of recommendations for neurosurgeons looking to translate our …
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Meet Captain Jim: From Navy Veteran to Research Volunteer
November 7, 2022
… Brooke McDonough. This film has been made possible with support from MJFF. Captain Jim and his family are … Markers Initiative (PPMI), as a way they can continue to serve, well beyond military duty. PPMI is enrolling … our guide . Christina Destro Associate Director Research Communications …
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Targets to Therapies: Aggregation and Synuclein Biology Target Validation
… Objective: The Targets to Therapies Program seeks to build a robust evidence … potential relevance to Parkinson’s disease. Funding will support projects to clarify human relevance, define …
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The Role of the Transcriptome in PD: A Novel Approach to PD Therapeutics
… in need of new biomarkers and effective therapies. To date, most of the studies have focused on DNA and … study these ignored molecules to find new therapies using a computational approach. Hypothesis: We hypothesize that … that can be used to nominate novel therapeutic targets. Study Design: This proposal has a sequential …
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Sniff Test: Surprising New Learnings About Smell Loss and Parkinson’s (Webinar Audio)
March 26, 2025
… signaling changes in the brain years before other symptoms are noticeable. Because of the link between smell and … researchers are very interested in understanding more about how people with smell loss go on to either develop a disease … with PD still are able to smell. To learn more about the latest research, tune into audio from this Third Thursdays …