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New Study Links Diabetes to Increased Risk of Parkinson's Disease
June 13, 2018
… in the scientific journal Neurology sheds new light on how diabetes affects Parkinson's disease risk. While the … between the two diseases was known, this study adds to our understanding of who is most at risk. Researchers at … rose to 49 percent greater risk for people experiencing complications from their diabetes and 400 percent for …
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A Small Molecule Approach to Correct Striatal Cholinergic Interneuron Dysfunction
… striatum undergo maladaptive biochemical changes leading to their hyperactivation under conditions of levodopa … (LID). We propose here an approach to precisely target hyperactive ChIs through a non-cholinergic receptor … that are enriched in ChIs has been identified by their comparison with the transcript profiles from 140 additional …
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Inhaled Levodopa for 'Off' Time Moves to FDA Review
February 20, 2018
… UPDATE September 13, 2018: Acorda Therapeutics, Inc today announced that the U.S. Food and Drug Administration … is known about inhaled levodopa -- clinical trial data, how the drug works and how it's made. This review process is … medication isn't working well. These "off" times can come on gradually, before it's time to take the next …
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Decoding Co-Pathological Mechanisms in Parkinson's Disease: From Molecular Interactions to Disease Progression
… abnormal proteins—α-synuclein, tau, and TDP-43—that clump together in brain cells. These protein clumps don't act … or exposure to environmental toxins, specialized cellular compartments called stress granules become rigid and trap … proteins, thereby exacerbating the disease. Understanding how these proteins interact during stress could reveal new …
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PPMI Patient Committee Member to Scientists: 'You Give Us Hope'
May 29, 2013
… PPMI investigator Victor Sung, MD, with Jean Burns Jean Burns was … friend Sheryl Jedlinksi. Jean is a member of the Patient Committee of the Parkinson’s Progression Markers Initiative … It just makes me want to participate in more studies to see how I can help. I’d like to close with a huge thank you to …
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Simple Blood Tests for Parkinson's Disease Derived from Genome-wide Expression Changes
… of Parkinson's disease relies on expert opinion. Autopsy studies, however, have demonstrated that even experienced … glass slide, known as microarray. We hypothesize that a comparison of the gene chip analyses of blood samples from …