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Structure-based Design of Pharmacological Activators of Parkin
… activity has been shown to protect neurons from death. Researchers hypothesize that increasing the activity of … complementary and will feed off one another. Relevance to Diagnosis/Treatment of Parkinson’s … the assays described above, the project will naturally feed into high-throughput screening of drugs that activate …
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Development of an HTS Assay to Break the Alpha-Synuclein-Glucocerebrosidase Feedback Loop
… points for drugs with a new mode of action. Relevance to Diagnosis/Treatment of Parkinson’s … project has the potential to provide a platform which many researchers and drug discovery organizations can access and … translate what we know about the alpha-synuclein-GBA link into ideas and molecules that will support the development …
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The Michael J. Fox Foundation Launches ''Parkinson's Clinical Trial Companion,'' Educational Suite Designed to Support Progress in Parkinson's Research by Increasing Patient Participation in Clinical Studies
April 3, 2018
… programmatic efforts to increase the flow of participants into clinical studies that urgently need them, The Michael J. Fox Foundation for Parkinson's Research (MJFF) launched the "Parkinson's Clinical Trial … patients and families about the power of participating in research and furnishes teams running clinical studies with …
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The Michael J. Fox Foundation Funds Three Research Teams to Seek Common Biological Pathways Underpinning Environment, Genetics and Aging in Parkinson's Onset and Progression
March 22, 2018
… disease (PD), The Michael J. Fox Foundation for Parkinson's Research (MJFF) announces a program investigating the … "With Parkinson's prevalence expected to double by 2040 to nearly 13 million people worldwide, our Foundation believes … research funders; increases the flow of participants into Parkinson's disease clinical trials with its online …
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Sohini Chowdhury, Deputy CEO of The Michael J. Fox Foundation for Parkinson's Research, Named to Crain's New York Business Notable Women in Health Care List
August 6, 2018
… Deputy CEO of The Michael J. Fox Foundation for Parkinson's Research (MJFF), has been selected by Crain's New York … record of leading MJFF's efforts to engage the patient and researcher communities in its mission to accelerate better … research funders; increases the flow of participants into Parkinson's disease clinical trials with its online …
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Effect of Alpha-Synuclein Depletion in Dopamine Neurons of Pre-Clinical Models
… these toxic species by further aggregating them and dumping into less harmful inclusions. Unfortunately, in the adult … alpha-synuclein dysfunction on physiology. Relevance to Diagnosis/Treatment of Parkinson’s Disease: … but even more importantly, will make it available for other researchers. This project was supported with a 2014 …