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A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: towards improving experimental reproducibility in α-synuclein research
January 11, 2020
… of alpha-synuclein (α-syn) aggregation from monomers into amyloid fibrils and Lewy bodies, via oligomeric … has helped to advance the field and provide insights into the biological properties and toxicity of different … and improving experimental reproducibility in Parkinson's research, we describe here a simple centrifugation-based …
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Screening Assays for Restored Protein Trafficking
… the basis for a high-speed drug screening assay. Impact on Diagnosis/Treatment of Parkinson’s Disease: … plan to also make these assays available for use by other researchers. … Research Tool …
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Is Parkinson’s Disease a Low-grade Inflammatory Bowel Disease?
… level either by Elisa and/or Western Blot. Relevance to Diagnosis/Treatment of Parkinson’s Disease: In view of … as proposed in our survey is a prerequisite for pursuing research in the field of inflammation in PD. This will set … Research Grants …
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GBA Sequencing and Detection of Mutations, Deletions, Insertions and Recombinations with the GBA Pseudo Gene
… This grant builds upon the research from a prior grant: Developing New Method for GBA … in GBA, and in controls without mutations. Impact on Diagnosis/Treatment of Parkinson’s Disease: If our plan is … mutations in this gene. It can be a useful tool for other research groups, and could be especially important for …
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Alpha-synuclein Aggregation Leads to Loss of Functional Forms of the Protein and Toxicity
… the result of the recruitment of endogenous alpha-synuclein into these aggregates, which effectively depletes the neuron … indeed depleted in these models. Relevance to Diagnosis/Treatment of Parkinson’s Disease: This study aims … that A) Endogenous alpha-synuclein gets recruited into experimentally induced aggregates, B) Our …
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Atomoxetine for Cognitive Impairment in Parkinson’s Disease
… and stiffness, but also leads to cognitive impairment. Research has shown that early loss of cells in a brain structure called the … baseline and after 10 weeks of ATM treatment. Relevance to Diagnosis/Treatment of Parkinson’s Disease: This trial will … Research Grants …