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Optimizing Metalloporphryins for Clinical Development Supplement 2
… This grant builds upon the research from a prior grant: Optimizing Metalloporphryins … dopaminergic neurons in the 6OHDA model. Importance of This Research for the Development of a New PD Therapy: Current … Research Grants …
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Antibody Testing in Postmortem Human Brain
… human brain samples presently held at the Banner Sun Health Research Institute in Sun City, AZ and the University of … contain thousands of PD and normal brains. Relevance to Diagnosis/Treatment of Parkinson’s Disease: Understanding … Research Tool …
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Development of Dopaminergic Cell Line Models of Alpha-synuclein Expression for High-throughput Drug Screenings and Monitoring of Alpha-synuclein Expression
… to alpha-synuclein. These iPS cells will be transformed into neurons that produce the alpha-synuclein-GFP fusion … compounds identified by drug screenings. Relevance to Diagnosis/Treatment of Parkinson’s Disease: Cell lines … neurons of both familial and idiopathic PD patients. Many research groups found that elevated levels of either the …
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(Supplement) Testing the Neuroprotective Efficacy of Modulating the Lysosomal Gene Atp6v0a1
… This grant builds upon the research from a prior grant: Testing the Neuroprotective … models of lysosomal stress and synucleinopathy. Impact on Diagnosis/Treatment of Parkinson’s Disease: If Atp6v0a1 … Accelerating Early Proof-of-Concept Testing of Promising PD Therapies …
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Developing a Binding Assay to Detect Toxic Alpha-synuclein Aggregates in Cerebrospinal Fluid and Plasma
… Rationale: The formation of toxic protein aggregates is an early step in the pathology of several neurodegenerative … and plasma can provide a means to diagnose PD and a window into its earliest stages of disease. Study Design: We will … to look for alpha-synuclein in plasma samples. Impact on Diagnosis/Treatment of Parkinson’s disease: PD is …
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Validation of IGF-1 as a Neuroprotective Agent in Pre-clinical Models of Parkinson’s Disease
… mechanisms underlying the effect of IGF-1. Relevance to Diagnosis/Treatment of Parkinson’s Disease: Despite that … Research Grants …