… investigators), with or without medications. Relevance to Diagnosis/Treatment of Parkinson’s Disease: To assess the … PD progression markers, if identified, will impact PD research and clinical trials tremendously. Anticipated … Our results are still being analyzed, but tau species clearly show strong correlation with Parkinson’s disease …

… periods of dysfunction before they die. By studying the early effects of Parkinson’s disease (PD) gene mutations … aims to uncover the earliest disturbances so that future research can correct them with drug treatments. Correcting … substantia nigra) releases the neurotransmitter dopamine into another brain region called the striatum. These two …

… of PD patients with different aSyn fiber densities (n=18 early, 20 moderate, and 21 advanced) and one consist of … remaining samples and subjects from the S4 study. Impact on Diagnosis/Treatment of Parkinson’s disease:  Detection of … patients would be a promising approach to improving the early diagnosis of PD as well as for monitoring disease …

… and neurorestorative therapy tailored toward treatment of early symptomatic GBA1-associated PD. Hypothesis:  We … dysfunction that develops in the GBA1 models. Impact on Diagnosis/Treatment of Parkinson’s disease:  PD is a … Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies …

… method for converting supportive, non-neuronal brain cells into functional dopamine-producing neurons leads to the … cells in the pre-clinical brain can also be converted into dopamine-producing neurons and that the resulting … generated neurons in the pre-clinical brain. Impact on Diagnosis/Treatment of Parkinson’s Disease: The proposed …

… drug to transform pro-inflammatory neurotoxic activities into responses that spare neurons normally lost in PD. We … test that can be used to screen people with PD for entry into clinical evaluations. Impact on Diagnosis/Treatment of Parkinson’s disease:  Our study seeks …