… of alpha-synuclein, the pathological hallmark of PD, occurs early in the course of the disease and may predate the … confirmed PD patients and controls. Relevance to Diagnosis/Treatment of Parkinson’s Disease:                 … cohort homogeneity in clinical trials; and (3) promoting early diagnosis, ideally in the pre-motor state. Anticipated …

… symptoms appear, and many people have a long journey to diagnosis. No objective test for Parkinson’s exists. If we are able to detect the disease at an early stage, we might be able to intervene and prescribe … that smart computer programs will allow us to detect early signs of PD from videos of people doing normal …

… profiles and that these differences will be apparent in the early stages of the disease. Study Design:  We will use data … groups and whether these differences can be identified early in the disease process. Finally, we will use publicly … blood, particularly in PD patients with dementia. Impact on Diagnosis/Treatment of Parkinson’s disease:  No treatments …

… Study Rationale:  Early indicators for Parkinson’s disease (PD), so-called … markers in cerebrospinal fluid and/or blood can support the early diagnosis and indicate the risk-status for PD, and that … Research Grant …

… may be a useful biological marker of disease. Impact on Diagnosis/Treatment of Parkinson's Disease: If a … Research Tool …

… dementia (FTD), respectively, and believed to be early disease indicators. Developing imaging agents to … of living patients would be useful and would allow for early diagnose and more accurate assessments of disease … positron emission tomography (PET) imaging scans. Impact on Diagnosis/Treatment of Parkinson's disease: PET tracers that …