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SudoScan as a Biomarker of Parkinson's Disease
… there is no single test that can be used to confirm a diagnosis of Parkinson's disease (PD) or a biomarker that … and whether SudoScan abnormalities might be present even in early (prodromal) Parkinson's stages. Study Design: We will … and people with REM sleep behavior disorder (an early/prodromal Parkinson's state). Abnormalities will be …
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α-Synuclein Pathology Beyond Lewy-related Pathology: α-synuclein Oligomers and Seeding Activity in LRRK2-related Parkinson’s Disease
… clumps and their ability to spread disease. Impact on Diagnosis/Treatment of Parkinson’s disease: … methods across laboratories, potentially improving early diagnosis of Parkinson's disease before symptoms … between protein clumps and disease-spreading activity, the research will identify new targets for treatments that could …
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Saliva Alpha-synuclein Levels in LRRK2 Mutation Carriers
… of disease activity) are needed to help determine a diagnosis of Parkinson's disease (PD) and to monitor disease … mutations by using one or more assays (tests). Impact on Diagnosis/Treatment of Parkinson's Disease: Human salivary … associated with collection) biomarker that can assist with early PD diagnosis when clinical diagnosis is the most …
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Using Nanobodies and Peptide Mimetics to Stabilize and Activate Mutant GBA
… techniques, we will introduce the most promising nanobodies into PD cellular and neuronal models that carry the GBA1 … an additional tool for preserving GBA1 function. Impact on Diagnosis/Treatment of Parkinson’s Disease: This study will … Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies …
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Creation and Testing of a Combined Cognitive Score in Parkinson Disease
… how to use or combine these test scores to best detect early cognitive changes in PD. This study will use the many … We think that combining a set of cognitive tests into a single composite score will provide a better method … Next Steps for Development: Once our results are published, researchers or health care providers might decide to use the …
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Identification of Genetic Signatures in the Blood as Biomarkers for Parkinson's Disease
… This grant builds upon the research from a prior grant: Identification of Epigenetic … represent a promising diagnostic tool to aid in the earlier diagnosis of PD, in the tracking of disease progression and … of disease progression, this feature might serve as an early diagnostic tool. Next Steps for Development: Once we …