… This grant builds upon the research from a prior grant: Specific Inhibition of … us to develop tests to detect it, which may be useful in early diagnosis. We also hope to find drugs to stabilize this structure and prevent it from converting into the form that is toxic to neurons. In addition, the …

… cells and disease pathology. Currently, the diagnosis of these diseases only takes place after the … imaging agents for these abnormal aggregations would enable early detection and the accurate monitoring of disease … and specificity for alpha-synuclein and tau.   I mpact on Diagnosis/Treatment of Parkinson’s disease: PET radiotracers …

… structure have been reported among PD patients by multiple research groups. None of these differences, however, appear … accumulation of alpha-synuclein.   Relevance to Diagnosis/Treatment of Parkinson’s Disease:                 … and treatment. The poor clinical accuracy of PD during the early phase of the disease is a major roadblock to finding …

… support several clinical applications ranging from earlier diagnosis, improved care with a deeper understanding on the … Fluid biomarkers enable deeper insight into underlying pathophysiology for diagnosis, prognosis, … sful, after Analytical and Clinical Validation, we will move into pilot launch with a selected clinic prior to scaling to …

… brain functions (e.g., mood, cognition, etc.). Recently, researchers demonstrated a neuroprotective effect of ghrelin … then utilize this tool to test ghrelin’s potential as an early Parkinson’s disease biomarker. Relevance to Diagnosis/Treatment of Parkinson’s Disease:   Having a …

… for maintaining independence and quality of life. Many research studies have have been conducted to measure walking … to answer many of the questions described above. Impact on Diagnosis/Treatment of Parkinson's Disease: Gait evaluation is useful in identifying early signs of Parkinson's and assessing disease …