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Identification of Epigenetic Signatures in Blood as Biomarkers for Parkinson's Disease
… represent a promising diagnostic tool to aid in the earlier diagnosis of PD, in the tracking of disease progression and … this signal changes as the disease progresses. Impact on Diagnosis/Treatment of Parkinson's Disease: Proper diagnosis … of disease progression, this feature might serve as an early diagnostic tool. Next Steps for Development: Once we …
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Nanoparticles for Detecting Parkinson's Disease Hallmarks with Magnetic Resonance Imaging
… physicians to diagnose Parkinson's disease (PD) at an early stage, to monitor disease progression or to assess the … If successful, this agent will make possible definitive diagnosis of the disease and objective evaluation of … which will help them find their way to the brain. Impact on Diagnosis/Treatment of Parkinson's Disease: If this study is …
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Clinical Evaluation of 18F-FD4 as a Potential Alpha-synuclein PET Imaging Biomarker
… agent for the measurement of alpha-synuclein. Impact on Diagnosis/Treatment of Parkinson’s disease: The ability to … levels of alpha-synuclein would be transformative for both diagnosis and the development of treatments because it is … This means that imaging could be used to identify patients early and also to monitor their progression in the presence …
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Analysis of the ENS Using Routine Colonic Biopsies as a Biomarker for PD: Optimizing Detection of Alpha-Synuclein Pathology and Assessment in LRRK2 Patients
… This grant builds upon the research from a prior grant: Analysis of the Enteric Nervous … of Parkinson’s disease (PD), namely Lewy neurites, in nearly 3/4 of PD patients and not in controls. The analysis … sporadic PD and LRRK2 parkinsonism may provide insight into the pathogenesis of PD. The early involvement of the …
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Peripheral Inflammatory Cytokine Profiling in Parkinson's Disease
… Study Rationale: A growing body of research suggests that inflammation contributes to … Our recent work suggests inflammation may be increased early in Parkinson's disease. We now plan to replicate our … who have been diagnosed with Parkinson's disease. Impact on Diagnosis/Treatment of Parkinson's Disease: Identifying …
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Evaluation of Digital Mobility Data to Identify Individuals at Risk of Developing Parkinson’s Disease
… diagnosed patients and even in the prodromal phase prior to diagnosis. Digital technology provides accurate, sensitive … Such tools therefore have the potential for identifying early changes in mobility associated with PD. Hypothesis: … and to monitor progression in individuals with prodromal or early-stage PD. Study Design: Participating subjects will …