… dSAA data at varying disease progression stages. Impact on Diagnosis/Treatment of Parkinson’s disease:               … but go beyond the state of the art in providing access to early diagnosis of PD. Next Steps for Development: With the … Research Grant …

… PD risk to study how these PD subtypes appear before diagnosis and how they progress over time. Hypothesis: We … Next Steps for Development: The next step is to intensify research into the underlying causes of different PD subtypes and to … Research Grant …

… This grant builds upon the research from a prior grant: Drug Rescue of PINK1: New … mutations in components of the PINK1/PRKN pathway lead to early onset Parkinson’s disease. Previous work by our … and then look to translate our cell-based assay results into models of Parkinson’s disease. Hypothesis: We believe …

… Doctors can’t see these changes in living people, making diagnosis slow and uncertain. Positron Emission Tomography … molecules behave in the body, including how well they get into the brain, how fast they leave, and how the body breaks … for binding strength, selectivity, and safety. Impact on Diagnosis/Treatment of Parkinson’s disease: A reliable asyn …

… utilize viral vectors (a tool to deliver genetic material into cells) as carriers for the parkin and alpha-synuclein … are processed in the cells and help us draw links between early abnormalities in cells and later events that lead to … without their own parkin. This result would aid in further research efforts to elucidate the effects of parkin on …

… donated by PPMI volunteers will be cultured and grown into neurons similar to those found in the human brain. A … cellular and molecular level to cause disease. Impact on Diagnosis/Treatment of Parkinson’s disease:  This work has the potential to inform diagnosis by defining molecular subtypes of disease. By …