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Preclinical Testing of a Novel Tracer for Imaging Alpha-synuclein Aggregates
… of MODAG-005 for use in clinical trials. Impact on Diagnosis/Treatment of Parkinson's Disease: … altered in PD and related diseases, would allow for the early and differential diagnosis of these disorders and for monitoring disease … Research Grant …
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A Phase I Retest Study of Imaging Tracer MODAG-005 in Parkinson’s Disease, Multiple System Atrophy and Healthy Volunteers
… imaging using radioactively labelled MODAG-005. Impact on Diagnosis/Treatment of Parkinson’s Disease: The successful … alpha-synuclein aggregates in PD and MSA would allow the early and differential diagnosis of these diseases and facilitate monitoring the … Research Grant …
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The BioFINDER Studies: Identifying Disease Stages and Effects of Co-morbidities in Neuronal Synuclein Disease
… focus on studying the different “stages” of NSD, from the early phases in which changes can only be detected using … with NSD alone. We also hypothesize that NSD will show clearly defined stages, beginning with a buildup of … the world measuring these types of clinical data. Impact on Diagnosis/Treatment of Parkinson’s Disease: The results of …
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A Randomized Controlled Trial of Neurocognitive and Supportive Therapy Interventions for Individuals with Parkinson’s Disease
… mood and quality of life will be evaluated. Relevance to Diagnosis/Treatment of Parkinson’s Disease: This study will … Research Grants …
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Development of Biomarkers Based on Brainstem Nuclei for Prodromal Parkinson's Disease
… Study Rationale: Early diagnosis of Parkinson’s disease (PD) requires development … effect of therapeutics. Our toolkit will be released to the research and clinical community to automatically identify … Research Resources Imaging Program …
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Deep Mutational Scanning of TMEM175
… This lack of functional information limits genetic diagnosis and slows the development of therapies that target … in human cells. Thousands of variants will be introduced into cells using a pooled approach, and their activity will … The variant map will be shared openly with clinicians and researchers and used to prioritize TMEM175 variants for …