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In Vivo Rescue of Dopamine Release Deficits via Kinase Inhibition in LRRK2 Mutant Mice
… of a LRRK2 mutation that display abnormalities in dopamine release and metabolism, which we hypothesize may be similar to the early brain changes in Parkinson’s patients. This study will … this tiny sample using a chromatographic technique. We will compare the amount of dopamine and metabolites in samples …
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The Michael J. Fox Foundation Releases New Guide, “Deep Brain Stimulation and Parkinson’s — From Decision-making to Daily Life with the Device,” to Answer Questions and Encourage Conversations on Available Treatments
June 15, 2021
… — authored by MJFF’s Senior Vice President of Medical Communications and movement disorder specialist Rachel … Funding from our industry partners allows the Foundation to maintain editorial oversight in the creation of high-quality … and potentially prevent PD. Launched in 2010, PPMI hosts an open-access data set that includes information on some …
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Examining the Role of LRRK2 and Glucocerebrosidase Dysfunction in Exosome-mediated Release of the Lipid Biomarker Bis(monocylglycero)phosphate in Parkinson's Disease
… the enzyme glucocerebrosidase, or GCase) are among the most common genetic risk factors for Parkinson’s disease (PD). … as PD biomarker. Our recent studies indicate that BMP is released in exosomes, membrane-enclosed vesicles secreted by … Study Design: Using cells derived from individuals with PD, we will investigate the impact of …
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Sonny Whelen Retires from Driving to Race Toward a Cure for Parkinson’s
July 16, 2012
… he’s had Parkinson’s disease. But this hasn’t stopped him from winning won two national championships in the Viper … speed Parkinson’s research progress. He’s turned several upcoming racing-related events in community fundraisers and is … more in the North American Road Racing Association’s press release. Lauren Shoor …
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Inhibiting Programmed Cell Death to Reduce Axonal Degeneration and Brain Inflammation in Parkinson's Disease
… of Parkinson’s disease (PD) and an attractive target for therapeutic intervention. We have demonstrated that a … is involved in this axonal degeneration, and that key components of the necroptotic cascade, including an enzyme … and properties of the most effective RIPK3 inhibitor candidate and by the capacity of this compound to treat PD …
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Parkinson’s Pillow Talk: An Open Conversation on Sex, Sleep and Intimacy
February 16, 2022
… Sexual problems are common in people with Parkinson's, but they can be difficult … closer look at Parkinson’s in the bedroom — covering topics from sleep to mood changes and their impact on sex and … In this episode, host and person with Parkinson's Larry Gifford leads a discussion with expert panelists: Rebecca …