… processes are already advanced by the time a clinical diagnosis is made. This delay contributes to the difficulty … of emerging, motor and non-motor prodromal PD features into a composite Prodromal Load Score. Study Design:  We … prevention trial of PD, entitled “Slow-SPEED.” Impact on Diagnosis/Treatment of Parkinson’s Disease:  If validated, …

… much NLRP3 is present. This diagnostic may help diagnose early onset disease, and will also support the first trials … We will also examine how much of the PET tracer gets into the brain, how specific its binding is and how long it lasts. Impact on Diagnosis/Treatment of Parkinson’s Disease: This diagnostic …

… Study Design : We aim to recruit 45 individuals with early to moderate PD and assign them to one of three … improvement for a year after the last infusion. Impact on Diagnosis/Treatment of Parkinson’s Disease:  Cell-based … the progression of PD. The results will provide insights into mechanisms of action and will lead to a large, …

… may be unique. Understanding which sleep changes happen early, and how they differ, may help doctors detect these … and thinking. Study Design: We will conduct two streams of research (1) recruiting 100 new participants; and (2) … decline and changes to sleep disturbance.  Impact on Diagnosis/Treatment of Parkinson’s disease: This study could …

… damaged mitochondria are degraded by mitophagy. One clue into how the process works comes from studying people with early onset PD who have rare mutations in two genes called … and examine the process of mitophagy. Importance of This Research for the Development of a New PD Therapy:     Many …

… This grant builds upon the research from a prior grant: Characterization of … diseases. The original grant demonstrated that the early drug candidate NPT001 (bacteriophage M13) … General Amyloid Interacting Motif (GAIM).  The supplemental research award supports investigation of a second generation …