… This grant builds upon the research from a prior grant: Assessing the Therapeutic … skin fibroblasts (a type of cell) from pre-clinical models into induced dopaminergic (iDA) neurons. We have provided … of any possible therapeutic application. Importance of This Research for the Development of a New PD Therapy:       This …

… This grant builds upon the research from a prior grant: Using LRRK2 Computer … but which both lead to similar Parkinson's disease diagnosis. In this combined model we will test whether … which are built on human data. Importance of This Research for the Development of a New PD Therapy: With the …

… System Atrophy  (MSA, and to aid in the differential diagnosis. This study seeks to leverage the NeuroExplorer’s … and understanding the  disease heterogeneity.  Impact on Diagnosis/Treatment of Parkinson’s disease: This approach … pathologies in movement disorders, aiding differential diagnosis and therapeutic development Next Steps for …

… This grant builds upon the research from a prior grant: Optimization of Dopamine D4 … dopamine) and optimized their strength and ability to pass into the brain. We then tested the lead molecule in a … lead to a novel treatment for LIDs. Importance of This Research for the Development of a New PD Therapy: As there …

… of dopamine in the cause and symptoms of PD. Impact on Diagnosis/Treatment of Parkinson's disease: We anticipate … -- objective measure of disease -- useful in Parkinson's diagnosis as well as clinical research. Next Steps for Development: Future clinical …

… This grant builds upon the research from a prior grant: Oxidized DJ-1 as a Biomarker … including human fluids such as blood and CSF. Relevance to Diagnosis/Treatment of Parkinson’s Disease:                 … DJ-1 levels in blood and CSF may be a biomarker of PD diagnosis and disease stages as well as disease …