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T Cell-mediated Autoimmune Responses in Parkinson's Disease
… The protein alpha-synuclein, which is misprocessed in nearly every case of Parkinson's disease (PD), forms the Lewy … we intend to characterize these responses and expand the research to investigate the self-regulatory features of the … to a range of potential misprocessing steps. Impact on Diagnosis/Treatment of Parkinson's Disease This work could …
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Axonopathy induced by overexpression of human -synuclein in the rat nigrostriatal dopamine system
… loss of the affected neurons occur later in the process. In early stages of the disease, therefore, the symptoms may be … by alpha-synuclein-induced axonal damage. Relevance to Diagnosis/Treatment of Parkinson’s Disease: The experiment … structure and function of axons, and obtain new insights into how alpha-synuclein-induced damage is spreading, from …
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Parkinson's Disease NeuroEPIC: A Study of Genes and the Environment
… PD cases; (2) record review by neurologists, to confirm diagnosis (probable and definite) and collect additional … new environmental factors that may provide further insight into causes of PD and pave the way for new therapies. … Genome Wide Association Study, using a custom made (for PD research only) chip, kindly donated by 23andMe that includes …
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Using Deep Learning to Evaluate Changes Associated with Parkinson’s Disease
… called deep learning offer exciting opportunities for the diagnosis and treatment of Parkinson’s disease (PD). Using … and reliably than is currently possible. Impact on Diagnosis/Treatment of Parkinson’s Disease: If successful, … disseminated and scaled, potentially providing an earlier diagnosis and a more quantitative, uniform and inexpensive …
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Development of a Protein Biomarker Panel to Measure Parkinson’s Disease Heterogeneity and Progression
… and heterogeneity of PD, which will support earlier diagnosis, improved care and a means of measuring disease … approach to corroborating pathophysiology. Impact on Diagnosis/Treatment of Parkinson’s disease: Our panel of … a variety of clinical applications including earlier diagnosis, evaluation of drug therapies and monitoring of …
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Characterizing the Immune Cells Present in the Blood and Cerebrospinal Fluid of People with Parkinson's Disease Associated with Mutations in LRRK2
… specific biomarkers, an approach that could facilitate the diagnosis and treatment of the disease. Study Design: In … those of age- and sex-matched healthy volunteers. Impact on Diagnosis/Treatment of Parkinson’s disease: Our goal is to … novel targets for drug development or identify markers for diagnosis and monitoring of individuals that have genes that …