… This grant builds upon the research from a prior grant: Developing New 18F-based Brain … by positron emission tomography (PET) scans can enable the diagnosis of degenerative disorders and help test new drugs … test how well drug candidates impact synaptic density, researchers will better be able to select which ones should …

… noninvasive way to track changes in the brain over time. Early research, including results from recent clinical trials, … dependable tool for tracking Parkinson’s disease. Impact on Diagnosis/Treatment of Parkinson’s disease: If proven … Research Grant …

… for imaging alpha-synuclein is available. This tool eludes researchers because it has been challenging to develop an … tissue from people with Parkinson´s disease. Impact on Diagnosis/Treatment of Parkinson’s Disease:              The … presence of alpha-synuclein protein deposits in patients at early stage, (ii) to help the prediction of disease …

… disease dementia. Therefore, MCI monitoring can be used for early identification of those PD patients at risk for the … of the MDS PD-MCI criteria, if necessary. Relevance to Diagnosis/Treatment of Parkinson’s Disease:                 … definition will allow clinicians, patients, caregivers, and researchers to communicate better. Anticipated Outcome:     …

… called alpha-synuclein builds up inside of brain cells. Research suggests that this protein accumulation damages the … with PD to assess alpha-synuclein affinity. Impact on Diagnosis/Treatment of Parkinson’s disease:  An … the concentration of alpha-synuclein in the brain at diagnosis and during PD progression, help determine which …

… describe a longitudinal cohort of patients with incident diagnosis of PD; … and extracted from the demographic, encounter, procedure, diagnosis, and pharmacy tables in the EHR to describe the … PD progression. Impact on Diagnosis/Treatment of Parkinson’s disease: …