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Fostering Knowledge of Gait in PD Through a Multifaceted Dissemination Approach
… they can better understand the progression, recognize early signs and take proactive steps to manage these issues, … evidence-based, comprehensive care backed-up by validated research. Targeted education for patients and care givers … to help in the application of theory to practice. Impact on Diagnosis/Treatment of Parkinson’s disease: We envision …
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Using the Emergence of New Symptoms as a Measure for Parkinson’s Disease Progression in Clinical Trials
… is an effective means of monitoring disease progression in early PD. In this study, we will repeat and confirm our … symptoms will provide a more sensitive means of monitoring early PD progression than the standard methods, which … with standard approach to using MDS-UPDRS scores. Impact on Diagnosis/Treatment of Parkinson’s disease: If successful, …
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Alpha-synuclein PET Imaging in Patients
… We developed [11C]SY08 for alpha-synuclein PET imaging. Our early findings in people showed increased brainstem binding … control (HC) participants. Here, we will build on our early experience to evaluate whether [11C]SY08 PET imaging … of [11C]SY08 across the diagnostic groups. Impact on Diagnosis/Treatment of Parkinson’s Disease: We currently …
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Inhibition of LRRK2 Roc-COR GTPase
… with Parkinson’s and a mutation in the LRRK2 gene. Recent research shows LRRK2 may be overactive in a sporadic (cause … disease. Study Design: Drugs bind to proteins like keys fit into locks. We are going to try about 2000 molecules (keys) … changes in the key until we get the right fit. Impact on Diagnosis/Treatment of Parkinson’s Disease: Our project may …
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Impact of LRRK2 Kinase Activity on Synaptic Vesicle Trafficking
… This grant builds upon the research from a prior grant: Impact of LRRK2 Kinase Activity … of LRRK2 pathological phosphorylation. Importance of This Research for the Development of a New PD Therapy: … Robust data coming from pre-clinical models resemble early findings from LRRK2 mutation carriers and suggest that …
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Developing Biosignatures for Parkinson's Disease Using Sense of Smell (Supplement)
… This grant builds upon the research from a prior grant: Developing Biosignatures of … candidate sensors to ultimately build an odor-based early diagnostic test. Hypothesis: We aim to show that … differently from control volunteer odors. Impact on Diagnosis/Treatment of Parkinson’s Disease: There is no …