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A Proof-of-Concept Study of Mitochondrial Drugs in Pre-Clinical Models of Parkinson’s Disease
… BDNF levels and markers of mitochondrial quality. Impact on Diagnosis/Treatment of Parkinson’s disease: Parkinson’s is a degenerative disease that, with early intervention, has the potential to be slowed or even … we can significantly alter disease progression in early-stage PD, and, potentially, offer those with …
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Developing New 18F-based Brain Tracers for Imaging Nerve Interactions (Synapses) in the Human Brain
… will lead to widespread use of this PET imaging scan for diagnosis and measuring therapeutic response in brain … test how well drug candidates impact synaptic density, researchers will better be able to select which ones should … are successful, the tracer could be used in clinical research to directly measure synaptic density in humans. …
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Objectively Measuring the Severity of Vocal and Speech-related Symptoms Associated with Parkinson’s Disease
… and development of speech deficits, particularly in the early phases of Parkinson’s disease (PD). Conducting such … biomarker would also provide a useful addition to clinical research and diagnostics. The aim of this study is to … as well as digital at-home voice assessments. Impact on Diagnosis/Treatment of Parkinson’s disease: If successful, …
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Targeted and Untargeted Mass Spectrometry-Based Proteome Investigation of Urine in Parkinson’s Disease
… also known as biomarkers — in Parkinson’s disease to enable early diagnoses and treatment response monitoring. Urine is … are at high risk of developing Parkinson’s. Impact on Diagnosis/Treatment of Parkinson’s Disease: There are … of diagnostic biomarkers could help to diagnose patients early before brain damage occurs. Prognostic biomarkers …
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Phenylbutyrate for Alpha-synuclein Clearance from the Brain
… Objective/Rationale: In our previous research, we have discovered that a drug called … works by transferring abnormal proteins from brain cells into the bloodstream. We now want to see if the drug works … of certain brain proteins in their blood. Relevance to Diagnosis/Treatment of Parkinson’s Disease: …
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Establishing the South Carolina Parkinson’s Disease Registry
… state. Established by South Carolina Parkinson's Disease Research Collection Act, this registry will facilitate … and build a team to support the registry. Impact on Diagnosis/Treatment of Parkinson’s disease: Once … data collected in the registry. In addition, recruitment into clinical trials will be facilitated for individuals who …