… Together with biochemical data, it provides novel insight into the regulation of LRRK2 kinase activity (protein … the first multi-domain model for LRRK2 to provide insights into the molecular activation mechanisms as well as the … of PD mutations on a structural level. Importance of This Research for the Development of a New PD Therapy: Mutations …

… on MOR, the supposedly antagonists were in fact separable into full antagonists, full agonists (which activate the … Description: Building upon this new knowledge, the MOR4LID research program will thus (i) test the origin of the … of the pathophysiology of LID and has allowed to clearly demonstrate that agonizing (instead of antagonizing) …

… This grant builds upon the research from a prior grant: Pre-clinical Evaluation of … in formulation and pharmacokinetic studies.  Impact on Diagnosis/Treatment of Parkinson’s Disease:              … The overall goal is to advance the lead compound into clinical trials in patients with Parkinson’s disease. …

… This grant builds upon the research from a prior grant: Preferential Targeting of … of 5-HT1A Receptors Promising Outcomes of Original Grant: Researchers investigated the effects of serotonin 5-HT1A … is successful, a drug candidate will be taken forward into clinical trials. …

… Scales to measure quality of life are important tools for research. However, it is unclear whether currently available scales for measuring quality of life take into account the priorities and values of an individual with … to measure quality of life in other diseases. Impact on Diagnosis/Treatment of Parkinson’s disease:  By ensuring …

… explore this interesting phenomenon, using a systematic research approach. Hypothesis: We hypothesize that by … during holiday trips that respondents make. Impact on Diagnosis/Treatment of Parkinson's Disease: If there is a … this study can provide the basis for further research into the positive impact of altitude on symptom severity in …