… Six PD subjects with levodopa-induced dyskinesia, 5 early PD subjects and 5 healthy subjects will undergo … data in PD subjects with dyskinesia will be compared with early PD subjects and healthy subjects to evaluate if … individuals with levodopa-induced dyskinesia. Relevance to Diagnosis/Treatment of Parkinson’s Disease: While a decrease …

… with idiopathic PD and healthy controls. Relevance to Diagnosis/Treatment of Parkinson’s Disease:                 … lymphocytes could be a potential non-invasive biomarker for diagnosis, monitoring for disease progression, and treatment … Research Grant …

… This grant builds upon the research from a prior grant: Nanoparticle Gene Therapy for … cell line-derived neurotrophic factor (GDNF) was compacted into nanoparticles, injected safely into the brain, and … Therapeutics, Inc. (Cleveland, Ohio). Importance of This Research for the Development of a New PD Therapy: The …

… disorder, which often precedes Parkinson's. Impact on Diagnosis/Treatment of Parkinson's disease: Identification … development. It may also help diagnose Parkinson's at an early stage. Next Steps for Development: If successful, this … Research Grant …

… the function and amount of the GCase protein. Impact on Diagnosis/Treatment of Parkinson's Disease: This project … then more work would need to be done to determine how early in the course of disease the GCase dysfunction occurs … Research Grant …

… for safety and efficacy in pre-clinical models. Impact on Diagnosis/Treatment of Parkinson’s Disease: Our … disease progression stages more accurately and allow early efficacy evaluation of new therapies. Next Steps for … Research Grant …