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Assessing the Aggregation of Alpha-synuclein in the Gastrointestinal Tract
… is valid, the GI tract might be a good place to spot the early signs of PD and to monitor PD progression over time. … studied for PD during life and after death. Impact on Diagnosis/Treatment of Parkinson’s disease: If PD starts in … Research Grant …
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Using Immune Cells to Treat Parkinson's Disease
… from forming by engineering additional genetic material into immune cells (T cells) in a patient. Hypothesis: We … alpha-synuclein clumping and brain cell death. Impact on Diagnosis/Treatment of Parkinson's disease: Patients' own T … such as those that use antibodies. Cells can freely travel into the brain where alpha-synuclein clumps are located …
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Establishing a Parkinson’s Disease Registry in West Virginia
… is well positioned to design a registry that could maximize research and clinical advancements, as its registry will be … such as The Michael J. Fox Foundation. Impact on Diagnosis/Treatment of Parkinson’s disease: Establishment … the world to use for clinical and epidemiological research into therapies, genetic links, and demographic links, …
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Genetic Factors that Influence Inherited Parkinson's Disease Associated with Changes in the GBA gene
… groups of people with GBA- associated disease. Impact on Diagnosis/Treatment of Parkinson's disease: Identifying … with a delayed onset of PD. It may also allow earlier diagnosis resulting from consistent follow-up with healthy … Research Grant …
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Advancement of Quantitative Disease Progression Modeling of Parkinson’s Disease
… studies of PD therapeutic trials involving subjects in the early stages of disease will be organized in a standard … its variability and identify its sources. Relevance to Diagnosis/Treatment of Parkinson’s Disease: … simulation. The current analyses will benefit the PD research community by updating previous disease models and …
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Phase IB Follow-up Study to Assess a Second Boost Immunization With AFFITOPE® PD01A in Those Who Participated in the AFF008 Program
… This grant builds upon the research from a prior grant: Phase IB Follow-up Study to … will be offered another boost of PD01A. Importance of This Research for the Development of a New PD … disease progression. These results will help advance PD01A into Phase II testing, the next development phase. …