… This grant builds upon the research from a prior grant: Structure Window into LRRK2: Kinase or Pseudokinase? Study Rationale: … by creating and studying artificial LRRK2 forms. Impact on Diagnosis/Treatment of Parkinson's Disease: Understanding … Research Grant …

… The mitochondrial proteome changes will also be entered into a database that will be freely accessible to other PD researchers. Relevance to Diagnosis/Treatment of Parkinson’s Disease:                 … Research Grant …

… have shown that normal dopamine neurons transplanted into Parkinson's cells quickly acquired this misfolded … alpha-synuclein in the form of PFFs will be injected into two parts of the brain: the striatum, which is affected … injected PFFs induce an abnormal immune response. Impact on Diagnosis/Treatment of Parkinson's Disease: Currently, the …

… We found that the pathology in LRRK2 Parkinson's falls into three distinct categories based on the presence of … which features occur in both types. Importance of This Research for the Development of a New PD Therapy: Our study … Research Grant …

… characterized, the pure Lewy body samples will be injected into the brain and the gut of models, which will then be … progression of dopamine neuron degeneration. Relevance to Diagnosis/Treatment of Parkinson’s Disease: This research will provide information on the process and time …

… challenge participants to address. The data will be split into a challenge and evaluation set.  Researchers from around the world will then be invited to … the evaluation set to choose the best measures. Impact on Diagnosis/Treatment of Parkinson’s Disease:              …