… present with similar clinical symptoms, especially at early stages. Though both involve the abnormal accumulation … metabolites, and lipids as potential biomarkers.  Impact on Diagnosis/Treatment of Parkinson’s disease:               … Research Grant …

… are due to selective CRAC channel inhibition.  Impact on Diagnosis/Treatment of Parkinson’s Disease: This research will identify an entirely new target for … their most promising compounds before selecting one to move into human trials for therapeutic drug candidacy. …

… This grant builds upon the research from a prior grant: Structural Insights into Activated Intermediates of Parkin Study Rationale: … of Parkinson's disease: Loss of Parkin causes a genetic, early-onset form of Parkinson's disease. Together with … Research Grant …

… This grant builds upon the research from a prior grant: Structure Window into LRRK2: Kinase or Pseudokinase? Promising Outcomes of … environments in the NASA space station. Importance of This Research for the Development of a New PD Therapy: A … Research Grant …

… for clinical applications, we will differentiate the iPSCs into midbrain dopamine cells and xeno-graft into pre-clinical models to determine long-term graft survival and functional improvement. Impact on Diagnosis/Treatment of Parkinson's disease: Replacing …

… of the genetics of Parkinson’s disease. Impact on Diagnosis/Treatment of Parkinson’s disease:   This project will give insight into how genetic variants that are tied to Parkinson’s risk … use of different genes. This understanding can give insight into the molecular mechanisms underlying the genetics of …