… In Parkinson's, the protein alpha-synuclein aggregates into clumps, which are a hallmark of the disease. Tau is a … the brain. A potent LRRK2 inhibitor will be introduced into pre-clinical models with and without a LRRK2 mutation … the effect of LRRK2 inhibitors on tau pathology. Impact on Diagnosis/Treatment of Parkinson’s Disease: If LRRK2 drives …

… affect enzyme function in human cells, now extending into more disease-relevant models and integrating genetic … Next, we will introduce a large library of GBA1 variants into stem cell–derived neurons carrying alpha-synuclein, and … certain activating variants might be protective. Impact on Diagnosis/Treatment of Parkinson’s disease:               …

… to define the locations more precisely. Impact on Diagnosis/Treatment of Parkinson’s Disease: As Parkinson’s … of these fibrils in the brain would potentially enable early detection of PD and better ways to evaluate the effect … Research Grant …

… any mutations onto known biological pathways. Relevance to Diagnosis/Treatment of Parkinson’s Disease:                 … will be of great relevance with respect to monitoring and early detection of cancer in these mutation carriers. … Research Grant …

… Initiative — have monitored a large group of people with early-stage PD for at least two years using a … on three types of measurements important for people in the early stages of PD: tremor, arm swing during gait, and … software for use in future clinical trials. Impact on Diagnosis/Treatment of Parkinson’s disease: The emergence of …

… for individuals with Parkinson’s disease (PD). With some early prototypes, we have helped a small number of people … falls, but these are more experimental in nature! Impact on Diagnosis/Treatment of Parkinson’s disease:  Changes in … Research Grant …