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Powered Clothing and Wearable Robotics for Improved Gait, Balance and Reduced Freezing in Everyday Life
… potential for the Parkinson’s community. With some early prototypes, we have helped a small number of … month to see how it impacts their everyday lives. Impact on Diagnosis/Treatment of Parkinson’s disease: Movement … Research Grant …
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From Omics to Action: A Multimodal Pipeline for Druggable Target Discovery and Real-world Validation in PD
… therapeutic development for PD patients. Impact on Diagnosis/Treatment of Parkinson’s disease: This project … in this study will move to laboratory testing and early clinical evaluation. These results will guide the … Research Grant …
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Further Validation of SIRT3 in a Parkinsonian Model
… This grant builds upon the research from a prior grant: Validation of Sirtuin 3 as a … using behavioral and post-mortem studies. Relevance to Diagnosis/Treatment of Parkinson's Disease: In this study, … neuroprotective potential of SIRT3 by infusing this protein into the brain region affected in PD (the substantia nigra). …
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Does Mitochondrial Dysfunction in the Skin Predict That in the Brain?
… always present and can vary in its severity. We and other researchers found mitochondrial dysfunction outside of the … We will recruit both people with PD and healthy volunteers into this study. Study participants will donate skin samples … have mitochondrial dysfunction in their brain. Impact on Diagnosis/Treatment of Parkinson's disease: Our project will …
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(SUPPLEMENT) Investigation of Small Molecules for Rescuing Lysosomal and GBA1 Deficiencies in GBA-associated Parkinson’s Disease
… This grant builds upon the research from a prior grant: Investigation of Small … where they act to produce a beneficial effect. Impact on Diagnosis/Treatment of Parkinson’s disease: Identification … Next Steps for Development: Compounds will be advanced into preclinical GBA-associated PD models to establish that …
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(SUPPLEMENT) Enhancing Brain Clearance Mechanisms to Limit Parkinson Disease Progression
… This grant builds upon the research from a prior grant: Using Sleep Modulation to … the removal of toxic proteins from the brain. Impact on Diagnosis/Treatment of Parkinson’s disease: This project … findings from this project will be directly translatable into human trials, to limit the buildup of toxic proteins in …