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Using Whole Genome Sequencing Data from LRRK2 Families to Identify Novel Rare Variants of LRRK2-associated Parkinson’s Disease
… LRRK2 G2019S–induced neurodegeneration in PD. To do this, researchers propose a four phase plan, including the (1) … identify novel genetic modifiers that will be (4) funneled into a validation scheme to directly test potential genetic … from patients with the LRRK2 G2019S mutation. Relevance to Diagnosis/Treatment of Parkinson’s Disease: Given the …
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Registry for the Advancement of Deep Brain Stimulation Therapy in Parkinson's Disease
… This grant builds upon the research from a prior grant: Registry for the Advancement of … that is focused on creating positive change. Data on clearly defined quality measures will be continuously … aid in generating large datasets that can provide insights into treatment patterns and outcomes of DBS. By collecting …
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Tracking Mobility and Symptoms of Parkinson's Disease with New Wireless Technology
… diary and undergo a basic assessment once a week. Impact on Diagnosis/Treatment of Parkinson's disease: This project … more data in less time, this technology could speed research and therapeutic development. It could also be used … If successful, the study will provide new insights into the lives of people with Parkinson's outside of the …
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Imaging Agents for Tauopathies and Alpha-Synuclein
… neurodegenerative disorders, in addition to aiding in diagnosis and tracking the effectiveness of new therapies. … and those with PD using sensitive assays (tests). Impact on Diagnosis/Treatment of Parkinson's disease: Our goals are to … Research Grant …
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Discovery of Selective PET Imaging Agents for Tauopathies
… and related neurodegenerative disorders, to aid definitive diagnosis, and to track the effectiveness of new therapies … and PD subjects using sensitive assay methods. Impact on Diagnosis/Treatment of Parkinson’s disease: … Research Grant …
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Developing Circuit-Targeting Optogenetic Strategies for Pre-Clinical Model Motor Circuitry
… other cell types. This provides substantial advantages for research into Parkinson’s disease (PD) pathophysiology and treatment, … targeting strategies to achieve this goal. Relevance to Diagnosis/Treatment of Parkinson’s Disease : In this … MJFF Research Grant …