… This grant builds upon the research from a prior grant: LRRK2 Role on Auto-Antibody … with the patient’s own tissues or cells. Relevance to Diagnosis/Treatment of Parkinson’s … is expressed in B cells and its mutations are related to early development of PD. Thus, the main objective of this …

… also influence neuronal glutathione content. Relevance to Diagnosis/Treatment of Parkinson’s Disease : It has long … been recognized that reduced neuronal glutathione is an early and characteristic hallmark of PD, and that reductions … there is a lack of information about thiol drug penetrance into the brain and the doses required to influence neuronal …

… human PD gene mutations can provide important insights into the molecular mechanisms implicated in PD and also … link the map to relevant behavioral measures. Relevance to Diagnosis/Treatment of Parkinson’s Disease:                 … Research Grant …

… validation screen to confirm activity on ATP10B. Impact on Diagnosis/Treatment of Parkinson’s disease:  If successful, … Development: Validated ATP10B activators will be advanced into lead optimization and preclinical development with the … Research Grant …

… and, potentially, discover novel viruses. Impact on Diagnosis/Treatment of Parkinson’s Disease: This study may … PD, which could provide innovative and impactful insight into PD pathogenesis and nominate potential treatment … Research Grant …

… forms the pathological processes can be studied in the very early (”pre-Symptoms & Side Effects”) phase to establish … even in a pre-clinical stage of disease.    Relevance to Diagnosis/Treatment of Parkinson’s Disease :   The … Research Grant …