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Evaluating a Gene Therapy that Restores Mitochondrial Function as a Treatment for Parkinson’s Disease
… a gene involved in mitochondrial quality control into cells and preclinical PD models will improve … survival and enhance their ability to function. Impact on Diagnosis/Treatment of Parkinson’s disease: There are … Research Grant …
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Phenotypic Characterization of BAC LRRK2 Transgenic Pre-clinical Models
… that may precipitate PD in humans. Relevance to Diagnosis/Treatment of Parkinson’s Disease: Characterization … show degeneration of their dopamine neurons, they did show early abnormalities of these cells, which suggested that … stress. Thus, these pre-clinical models appear to show very early signs of LRRK2-associated disease. As such, they may …
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Gastrointestinal Function in Parkinson's Mice
… This grant builds upon the research from a prior grant: Evaluation of Gastrointestinal … questions, the answers to which will substantially drive research into GI symptoms in PD in the future. First, alpha-synuclein … MJFF Research Grant …
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LRRK2-Mediated Rab Protein Phosphorylation in Monocytes and Neutrophils in Parkinson's Disease
… disease. Studying this gene's effects has provided insight into the physiological processes that lead to genetic and … them for the LRRK2 and Rab phosphorylation assay. Impact on Diagnosis/Treatment of Parkinson's Disease: Our findings may … Research Grant …
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Discovery and Development of Parkin Activators as Therapies for Parkinson’s Disease
… Small molecule parkin activators can be optimized into therapeutic molecules to restore mitochondrial function … candidates for further therapeutic development. Impact on Diagnosis/Treatment of Parkinson's Disease: Laboratory data … Research Grant …
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PPM1H Activators for the Treatment of Parkinson’s Disease
… the ability to increase the activation of PPM1H. Impact on Diagnosis/Treatment of Parkinson’s Disease: Activators of PPM1H can be further developed into drugs that are safe to give to people with PD. This … Research Grant …