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A Novel Preclinical Candidate for Reducing Alpha-synuclein Aggregation in Parkinson’s Disease
… also plan to optimize the drug for oral delivery. Impact on Diagnosis/Treatment of Parkinson’s disease: Following the … on the pathway to be successful in IND filing and moving into Phase I clinical trials. … Research Grant …
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Assessment of Artificial Intelligence (AI) and Blood-Brain Barrier Technology
… drugs across the protective blood-brain barrier (BBB) and into the brain. The objective of this study is to identify … out and understand potential PD applications. Impact on Diagnosis/Treatment of Parkinson’s disease: This project … Research Grant …
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Development of a Tau Oligomerization Inhibitor for the Treatment of Parkinson’s Disease
… Candidate suitable for IND-enabling studies. Impact on Diagnosis/Treatment of Parkinson’s disease: Targeting Tau … Disease and significantly impact patients who have early-diagnosis. Next Steps for Development: Following this project, Psy Therapeutics will advance the program into IND-enabling studies as we drive towards entering Phase …
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DPI-289, a Novel Bi-Functional Delta Agonist / Mu Antagonist (DAMA) as a Therapy for Parkinson's Disease
… potential and anti-dyskinesia activity. Relevance to Diagnosis/Treatment of Parkinson’s Disease: Initial early use of this compound may postpone the need for … Research Grant …
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Characterization of LRRK2 Inhibitors for Advanced Drug-like Properties
… toxicity studies. Positive results will lead to advancement into late stage optimization and pre-clinical studies. … Project Description: To progress a compound into clinical trials, a number of pre-clinical tests must be … receptor panel and extended kinase panel. Relevance to Diagnosis/Treatment of Parkinson’s …
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Convergence of LRRK2 and GBA1 in the Pathogenesis of Parkinson's Disease
… (an enzyme made by the GBA gene). Impact on Diagnosis/Treatment of Parkinson's disease: Using this … interaction between LRRK2 and GBA1 could provide insights into the therapeutic efficacy of LRRK2 kinase inhibitors in … Research Grant …