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Targeting of Alpha-synuclein and SNARE Complex Dysfunction to Restore Synaptic Dopamine Release in a Model of Parkinson Disease Pathology
… starts at the synapse, the part of the neurons where the release of dopamine occurs, dysfunction of which leads to … a chaperon protein involved in the assembly of a protein complex called SNARE, involved in the release of … stages of PD. Project Description: Alpha-synuclein, the main protein that forms the Lewy bodies that are the …
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NeuroX profiling of samples from the PPMI prodromal and genetic cohorts, the LRRK2 cohort consortium and the BioFIND cohort
… Study Rationale: This work aims to provide genetic information at common genetic variants and rare genetic variants that have … be incorporated in to current genetic analyses that are ongoing within the laboratory. Impact on Diagnosis/Treatment …
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Targeting Necroptosis to Stop Axonal Degeneration in Parkinson's Disease
… a cell body and projections called axons by which neurons communicate. Previous studies have shown that degeneration … evidence that axons degenerate by a mechanism called necroptosis. Hypothesis: In this project, we will study whether … a collaborative work with a pharmaceutical company in order to perform a drug screening or to design and develop a …
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Michael J. Fox Foundation Releases First and Largest Data Set of Self-Reported Outcomes on COVID-19 and Parkinson’s Disease
July 14, 2020
… and shelter-in-place guidelines on the Parkinson’s community Tremendous response over 30 days reflects … symptoms and disruptions in care. The survey, which remains open in Fox Insight, was designed in consultation with …
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Toll-like Receptor Inhibition to Block Alpha-synuclein-induced Pro-inflammatory Signaling and Cytokine Release
… play a critical role in the immune system's response to foreign pathogens that can trigger adverse inflammatory … signaling. We will measure this effect by analzying release of pro-inflammatory molecules (cytokines). We will … strategy for slowing PD progression. The data generated from this project will provide a clear go/no-go decision …
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The Michael J. Fox Foundation Relaunches Parkinson’s Clinical Study Matching Tool, Fox Trial Finder, with Optimized Features and Accessibility
February 25, 2020
… — the more than 91,000 patient and family participants to date — with a simplified experience to more easily find … said MJFF Deputy CEO Sohini Chowdhury. “We heard our community’s feedback and redesigned the tool to better … currently houses more than 500 actively recruiting studies from 40 countries. And since the platform’s original launch …