-
Examining the Role of Cannabinoid Receptor 2 in Inflammatory Responses Triggered by Alpha-synuclein
… interact with alpha-synuclein aggregates. Impact on Diagnosis/Treatment of Parkinson’s disease: Other labs have … the trafficking of immune cells from the circulation into the brain in PD. Understanding how CB2 regulates the … Research Grant …
-
Interpretation of Accelerometer Data with Deep Learning
… small, we can segment the long stretches of 24/7 record into short chunks, generating large amount of training examples. Impact on Diagnosis/Treatment of Parkinson's Disease: The study will … Research Grant …
-
Restoring the Blood-brain Barrier to Prevent Dissemination of Alpha-synuclein and Progression of Parkinson’s Disease
… of the blood-brain barrier to block the passage of toxins into the brain and that this disruption of barrier function … the health of brain cells, such as neurons. Impact on Diagnosis/Treatment of Parkinson’s disease: This study will … Research Grant …
-
Gut Inflammation and Microbial Imbalance in Parkinson’s Disease
… of colon samples obtained from autopsies. Impact on Diagnosis/Treatment of Parkinson’s disease: This work will … and the microbiome in PD. Our findings could translate into treatments that reduce PD risk or severity by targeting … Research Grant …
-
Preclinical Development of Disease-modifying Therapies for Treating Parkinson’s Disease
… the compound in appropriate animal models. Impact on Diagnosis/Treatment of Parkinson’s disease: Preclinical … safety and tolerability characteristics to move forward into further clinical development, including IND-enabling … Research Grant …
-
Potent Inhibitors of Deubiquitinating Enzyme USP14 as Inducers of Parkin-independent Mitophagy
… disease. Study Design: Our USP14 inhibitors are injected into pre-clinical models that have a condition essentially … physiological relevance in human neuronal cells. Impact on Diagnosis/Treatment of Parkinson’s disease: The USP14 … Research Grant …