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Multi-tracer positron emission tomography (PET) functional imaging as a tool to assess the relevance of rodent LRRK2 models to the human neurochemical phenotype associated with LRRK2 mutations related Parkinsonism
… LRRK2 mutations and Parkinsonism. Importance of This Research for the Development of a New PD Therapy: If imaging … mutation-related neuronal abnormalities and identify early mutation-related alterations to provide a target for … MJFF Research Grant …
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Biomarker Battery Assessment in LRRK2
… This grant builds upon the research from a prior grant: Parkinson's Disease, Ashkenazi … summary score that best separates the groups. Relevance to Diagnosis/Treatment of Parkinson’s Disease: Because some … battery to identify at-risk individuals, could improve early detection of PD, and set the stage for earlier …
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Generation and Characterization of iPS Neurons from PINK1- and Parkin-linked Parkinson's Disease
… from patients with Parkinson’s disease can be reprogrammed into pluripotent stem cells (iPS) and subsequently … iPS neurons. We will collaborate with the NINDS PD iPS Cell Research Consortium to optimize the generation and … to rescue any abnormalities in phenotypes. Relevance to Diagnosis/Treatment of Parkinson’s Disease: There is an …
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Analysis of a Viral Non-coding RNA as a Novel Therapeutic in a Chronic MPTP Pre-clinical Model of Parkinson's Disease and its Mechanism of Mitochondrial Protection
… to the brain, but also when it was delivered by injection into the bloodstream. In both cases, the viral RNA inhibited … experimentally and this works when it is delivered directly into the brain or intravenously. This therapy thus … results in protection of these neurons. Importance of This Research for the Development of a New PD Therapy: We have …
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Rab Detection Initiative
… proteins can be determined with high precision. Impact on Diagnosis/Treatment of Parkinson's Disease: Since LRRK2 … developed to detect these proteins could be incorporated into clinical trials to determine the optimal dose of LRRK2 … Research Grant …
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Probing Nurr1 Expression in Parkinson’s Disease
… established biobank and patient population. Relevance to Diagnosis/Treatment of Parkinson’s Disease: We will confirm … the PD-linked Nurr1 as well as Nurr1-responsive genes and early-stage PD — an important step towards translating genetic and transcriptional clues into a biomarker potentially useful as companion diagnostic …