… This grant builds upon the research from a prior grant: Structural and Chemical … structure and kinase/GTPase activity. Importance of This Research for the Development of a New PD Therapy: We … of our current structure of LRRK2, and (II) insight into the composition and chemical modifications in …

… This grant builds upon the research from a prior grant: LRRK2-Mediated Rab Protein … Parkinson’s disease has provided considerable insights into the development of both familial and non-familial forms … and bank them for LRRK2 and Rab testing.      Impact on Diagnosis/Treatment of Parkinson’s Disease: Our findings …

… clear the protein from the brain, block its transformation into toxic species, or ameliorate the consequences of … characterize these preliminary hits. Relevance to Diagnosis/Treatment of Parkinson’s Disease: If successful, … evaluation in pre-clinical model studies and translation into clinical trials.   …

… from patients with Parkinson’s disease can be reprogrammed into pluripotent stem cells (iPS) and subsequently … iPS neurons. We will collaborate with the NINDS PD iPS Cell Research Consortium to optimize the generation and … and PINK1 mutations associate with autosomal recessive early-onset Parkinson’s disease. As murine genetic deletion …

… This grant builds upon the research from a prior grant: Investigating the Role of LRRK2 … the brain. A potent LRRK2 inhibitor will then be introduced into pre-clinical models — including some that feature an … these inhibitors can alleviate tau pathology. Impact on Diagnosis/Treatment of Parkinson’s Disease: If LRRK2 drives …

… recovery. We will also perform tests to gain insight into the mechanism of action and to evaluate the safety of the compounds. Relevance to Diagnosis/Treatment of Parkinson’s Disease:   If glycine … inhibitors promote the growth of dopaminergic processes into the dopamine-depleted striatum in a toxin-based …