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PERK Signaling in Parkinson’s Disease Progression
… This grant builds upon the research from a prior grant: The Unfolded Protein Response … of both proteins in nigral degeneration. Importance of This Research for the Development of a New PD Therapy: Successful … targets and accelerate the translation of basic research into clinical studies. Final Outcome The PERK protein is …
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Neuroimaging Markers Predict Cognitive Decline in PD
… This grant builds upon the research from a prior grant: Neuroimaging Markers Predict … To reach a final conclusion therefore, additional years of research are required to supplement the original 3 year … of treatment in PD. Amyloid toxicity is an acknowledged early event in Alzheimer’s disease, and is hypothesized to …
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The Role of Amyloid in the Progression of Cognitive Impairment in PD: A Prospective Cohort Study
… persons who do not have the amyloid protein. Relevance to Diagnosis/Treatment of Parkinson’s … functions offering a unique window of opportunity for early intervention. Anticipated Outcome: We expect … MJFF Research Grant …
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Expanding Genetic Analyses in Parkinson’s Disease
… but also to inform drug development efforts. However, many researchers do not have the required expertise to conduct … We hypothesize that in addition to conducting genetic research, providing user-friendly genetic data and offering … on proposed genetic research projects. Impact on Diagnosis/Treatment of Parkinson’s disease: A greater …
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Dynamics of Alpha-synuclein Aggregation in Dopamine Neuron Degeneration and Recovery
… This grant builds upon the research from a prior grant: Reversing Pre-existing … therapies for Parkinson’s disease in our original funded research, we will continue to identify the toxic species of … for PD pathologies in dopamine neurons. Importance of This Research for the Development of a New PD Therapy We …
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Longitudinal Endpoint Optimization to Provide an Assessment of Relevant Drugs in Parkinson’s Disease (LEOPARD-PD)
… intervention in Parkinson’s disease (PD). The goal of this research is to collect longitudinal data using the PD-HI and … development for people with PD. Hypothesis: This research seeks to determine the longitudinal performance … characteristics of the study sample population. Impact on Diagnosis/Treatment of Parkinson’s disease: This research …