… trial was open label (no placebo control group), additional research is needed to understand the potential clinical … with The Cure Parkinson's Trust and the Van Andel Research Institute to design a randomized, double-blind, … ; Tanya Simuni, MD ; and Charles Venuto, PharmD . Impact on Diagnosis/Treatment of Parkinson's Disease: If nilotinib is …

… This grant builds upon the research from a prior grant: Genetic Factors that Influence … (hallmark pathology of PD). Importance of This Research for the Development of a New PD Therapy:       The current research will help us determine if TMEM175 and CTSB affect …

… model to make this technique ready for translation into a clinical trial in PD patients. Project Description:  … and compared to classical DBS and l-dopa.  Relevance to Diagnosis/Treatment of Parkinson’s Disease:   Classical DBS … model to make this technique ready for translation into a clinical trial in PD patients.   Final Outcome Our …

… brain and subsequent brain cell death. Importance of This Research for the Development of a New PD Therapy: This research will allow us to confirm the therapeutic potential … we could advance to human clinical studies. Moreover, this research will give us a deeper insight of the biological …

… This grant builds upon the research from a prior grant: Developing Biosignatures of … providing a novel basis for Parkinson's biomarker research. Our customizable MouSensor technology allows us to … super-sniffer mice to advance the identification of early-stage Parkinson's biomarkers in sebum. In a pilot …

… disease (PD). Developing an imaging tracer may allow researchers to quantify this receptor in subjects with the … We hypothesize that a radiolabeled compound will allow researchers to measure the quantity of the mglur4 receptor … to evaluate their distribution pre-clinically. Impact on Diagnosis/Treatment of Parkinson’s Disease:              …