-
Parkinson's Disease Genetics Sequencing Consortium
… and industry to coordinate and accelerate PD genetics research. The consortium, using the cloud computing via … browsing of data and summary statistics. Impact on Diagnosis/Treatment of Parkinson's Disease: The … knowledge of Parkinson's. The creation of a public-facing research resource will accelerate further advances in PD …
-
GBA Variations, Cholinergic Degeneration, and Cognitive Decline in Parkinson’s Disease
… complete cognitive and motor-symptom assessment. Impact on Diagnosis/Treatment of Parkinson’s Disease: The current … results will improve the selection of subjects for future research, including disease-modification trials. Next Steps … To move towards personal treatment approaches, future research in pre-clinical and clinical trials can be informed …
-
Mechanisms of LRRK2 Membrane Association
… This grant builds upon the research from a prior grant: Regulation of LRRK2 Membrane … that are available to the Parkinson's disease (PD) research community to test specific LRRK2 amino acids for … LRRK2 changes using mass spectrometry. Importance of This Research for the Development of a New PD Therapy: Mutations …
-
Developing New Tracers for Imaging Synapses in the Brain
… This grant builds upon the research from a prior grant: Imaging Agents for Tauopathies … clinical trial in the United States and Canada. Impact on Diagnosis/Treatment of Parkinson's Disease: With a tracer that accurately measures synaptic density, researchers will be able to select the best therapeutic …
-
Charting a Path to Success for Clinical Trials in Patients with Inherited, GBA-linked Parkinson's Disease: PPMI Supplement
… This grant builds upon the research from a prior grant: GBA Meta-analysis Initiative: … -- disease indicators -- for tracking the progression of early-stage Parkinson's disease (PD) with an unknown cause. … tools to measure disease progression. Importance of This Research for the Development of a New PD Therapy: Identified …
-
LRRK2 Phosphatases Confirmation
… This grant builds upon the research from a prior grant: Identification of the LRRK2 … (PD) have yet to be precisely defined; however current research indicates that the Leucine Rich Repeat Kinase 2 … phosphatases in dephosphorylating LRRK2. Importance of This Research for the Development of a New PD Therapy: …