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Non-dopaminergic imaging biomarkers as tools for early PD - testing the Braak Hypothesis
… Many recent studies have suggested that we need to expand research in Parkinson's disease to study symptoms other than the typical motor symptoms of … can be initiated and monitored effectively. Final Outcome While no significant differences were observed between …
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Utilizing Novel Tracers to Determine the Distribution of Therapeutic Agents In Vivo
… therapeutics for Parkinson’s disease. The explored compounds will be infused directly into the brain of npre-clinical models and will be chemically … drugs through catheters implanted into the brain have shown promise but have had variable results. This study will …
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Optimizing Metalloporphryins for Clinical Development Supplement
… Metalloporphryins for Clinical Development Promising Outcomes of Original Grant: The overall goal of this ongoing proposal is to determine if a newly developed series of … designed to penetrate blood brain barrier shows promise for treatment of Parkinson’s disease. The goal …
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Focused Ultrasound to Treat Parkinson’s Symptoms on Both Sides of the Body Approved
July 14, 2025
… for the management of Parkinson’s-related movement, or motor, symptoms. The approval is an advance in focused … control symptoms and improve life with Parkinson’s.” How Does Bilateral FUS Work? FUS is an incisionless … tremor, and in 2021 for additional motor symptoms and complications, like dyskinesia and ups and downs in symptom …
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Increasing Endogenous Neurogenesis Using Neurosteroids: A Novel Therapeutic Strategy to Treat Parkinson's Disease
… Objective/Rationale : We will test a locally produced brain chemical that increases the generation of new neurons to replace the damaged neurons in Parkinson disease (PD). … drug as a treatment for Parkinson’s disease. Anticipated Outcome : We anticipate that this chemical will reduce the …
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Science Translational Medicine: Parkinson’s Disease Biomarkers Are Needed to Accelerate Therapeutic Development
April 20, 2011
… By Todd Sherer ABSTRACT: Biomarkers for detecting the early … of new treatments. Such biomarkers could be used to identify individuals at risk for developing PD, to … to track disease progression with precision, and to test the efficacy of new treatments. Although some progress …