… This grant builds upon the research from a prior grant: LRRK2 Effects on Neural … reproducible LRRK2 biological targets. Importance of This Research for the Development of a New PD Therapy: The … Research Grant …

… This grant builds upon the research from a prior grant: Advancing PINK1 Knockout Models … are most altered by PINK1 deficiency. Importance of This Research for the Development of a New PD Therapy: The … Research Grant …

… Study Rationale: Researchers recently proposed defining Parkinson’s disease … data that has already been collected in previous or ongoing research projects that followed people with PD over time. Impact on Diagnosis/Treatment of People with Parkinson’s disease: Our …

… model and viral vectors that can deliver the gene into the brain to target expression of ion channel gene … agents and anatomical identification. Relevance to Diagnosis/Treatment of Parkinson’s Disease: LID is one of … DT-A expression selectively eliminated ChIs when injected into striatum. The depletion of ChIs markedly attenuated …

… Objective/Rationale: Many researchers believe that placebo treatments may have … in patients’ optimism and expectations. Relevance to Diagnosis/Treatment of Parkinson’s Disease: Though many … systems are affected by placebo in PD will provide insight into whether clinical trials should be designed to enhance …

… This grant builds upon the research from a prior grant: Preferential Targeting of … Study Promising Outcomes of Original Grant: These researchers are investigating the activity of novel drugs … Supplemental Investigation:            This supplemental research is aimed at investigating two important questions. …