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Delivery of Cerebral Dopamine Neurotrophic Factor with Microbubbles and MRI-guided Focused Ultrasound (Supplement)
… This grant builds upon the research from a prior grant: Delivery of Cerebral Dopamine … CDNF microbubbles and the drug alone. Importance of This Research for the Development of a New PD Therapy: … has limited clinical use. Noninvasive drug delivery for early-stage patients throughout the diseased regions may be …
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Small Molecules That Promote Mitochondrial Movement as a Parkinson's Disease Therapy
… This grant builds upon the research from a prior grant: Promoting Mitochondrial … mitochondrial movement in those cells. Importance of This Research for the Development of a New PD Therapy: Because … Research Grant …
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The Transfer of Alpha-Synuclein: Mechanistic and Therapeutic Studies
… (PD) investigators capitalizes on their extensive PD research experience and new understanding of the … will exploit these new insights and harness the researchers’ collective expertise to screen MAbs from one of … PDD with a pharmaceutical company partner. Relevance to Diagnosis/Treatment of Parkinson’s Disease: This project …
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Developing a Method for Detecting Alpha-synuclein in the Acidic Cell Compartments in Which It Accumulates
… To track the fate of alpha-synuclein in neurons, researchers use imaging tools (‘reporters’) consisting of … test tube and when produced in cultured neurons. Impact on Diagnosis/Treatment of Parkinson’s disease: The alpha-synuclein reporter developed here will enable researchers to better understand how protein aggregates are …
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Determining Optimal Cognitive Measures and Clinical Trial Endpoints in Lewy Body Disorders
… recommendations through group consensus. Impact on Diagnosis/Treatment of Parkinson’s disease: This project could impact how researchers design and conduct clinical trials for cognitive … therapies. Our results will help guide clinicians, researchers and regulatory agencies in industry and the FDA …
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Personalized Parkinson Project (PPP)
… changes over time. The collected data will be shared with researchers worldwide to help develop better treatments and personalized care. Impact on Diagnosis/Treatment of Parkinson’s disease: This … symptoms over time. This data will be shared with approved researchers worldwide, ensuring privacy of the participants …