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Genetically Encoded Fluorescent Biosensors for Live-cell, Subcellular Detection of Distinct α-synuclein Aggregation States
… are not understood. Here we create tools that allow researchers to directly visualize, in living cells and … and dissolution in cells and animals will transform PD research — both in terms of basic science and for screening … PD, and several potential helpful interventions. Impact on Diagnosis/Treatment of Parkinson’s disease: …
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Consortium to Identify LRRK2 Modifiers of Age of Onset
… Project Description: The project is divided into 3 phases. The planning phase will be overseen by … phase will involve a team of analysts from the contributing research studies implementing the analytic plan developed in … study might be designed and implemented. Relevance to Diagnosis/Treatment of Parkinson’s Disease: …
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Registry for the Advancement of Deep Brain Stimulation Therapy in Parkinson's Disease (RAD-PD)
… could provide, the registry will help clinicians and researchers a) understand the clinical and socioeconomic … for a DBS registry in PD will be created. Impact on Diagnosis/Treatment of Parkinson's disease: Once implemented, the registry will help researchers determine the optimal treatment for and impact …
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Developing a Reliable Clinical Test for pS129 Alpha-synuclein
… Study Design: The Michael J. Fox Foundation for Parkinson's Research (MJFF) will provide cerebrospinal fluid samples to our team and to two other research teams that partnered with us for the purposes of … is to determine how reliable the tests are. Impact on Diagnosis/Treatment of Parkinson's disease: If its …
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Role of H1N1 Influenza Virus in the Etiology of Parkinson's Disease
… sequalae in the nervous system. We will examine mice both early in the infectious stage (days 0-21) as well as long … measurements using a microbead assay Relevance to Diagnosis/Treatment of Parkinson’s Disease: … MJFF Research Grant …
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Development of Analytic Tests to Use as Nilotinib Companion Diagnostics in Parkinson's Disease
… of determining whether nilotinib is working. Unfortunately, researchers have not yet been able to detect phosphorylation … those with Parkinson's and healthy individuals. Impact on Diagnosis/Treatment of Parkinson's disease: We believe our … if successful, these tests will be made available to the research community and used in upcoming clinical trials. If …