-
Inhibition of PKA as a Mechanism to Reverse LRRK2 Mutation-induced Parkinson's Disease
… on these results we propose that our deepening knowledge of how LRRK2 dysregulation of PKA results in Parkinson’s-like symptoms could provide strong rationale for new therapeutic … we may be able to pursue this pathway as a therapeutic target. Next Steps for Development: Although it is a …
-
Late-preclinical Development of a Differentiated TRPML1 Agonist to Slow Progression of Parkinson’s Disease
… as the cell’s degradation and recycling center. Lysosomes stop working properly in Parkinson’s disease and accumulate … In this study, we will further optimize and identify a lead compound to advance into preclinical safety studies. These …
-
Team Fox to run in the ING NYC Marathon this Sunday (VIDEO)
November 1, 2012
… New York City marathon for The Michael J. Fox Foundation to raise money for Parkinson's disease research. Three … raised $90,000 for Parkinson's research. Learn more on how you can become a Team Fox Athlete . Laxmi Wordham …
-
National Plan to End Parkinson’s Act Will Be Reintroduced in New Congress in 2023
December 29, 2022
… December 29, 2022: Community advocacy has been critical to pushing forward The National Plan to End Parkinson’s Act … before the end of the year. For more information about how this bill will work its way through Congress, check out …
-
Breaking News: A New Dyskinesia Drug Will Be Submitted to FDA This Year
September 21, 2016
… A new formulation of amantadine to better treat levodopa-induced dyskinesia is entering the … reduction in LID at 12 weeks in patients receiving ADS-5102 compared with placebo, as assessed by the Unified Dyskinesia … met its primary endpoint.[...] Results from the study showed an improvement in activities of daily living (ADLs) in …
-
Pathophysiology of Neural Circuits Underlying Pain in Prodromal to Advanced Parkinson’s Disease
… ineffectiveness of these treatment strategies may be due to a lack of understanding of the biological processes … normally curb the experience of pain. Our new results show that mice that experiences changes in the brainstem … techniques from multiple scientific disciplines to show how cells in the brainstem and spinal cord that are …