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Inflammatory Phenotypes in Differentiated Human LRRK2 and GBA Mutation IPS Cell Lines
… GBA) is also related to inflammation. Importance of This Research for the Development of a New PD Therapy: Drugs … Research Grant …
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Searching for New Genes That Control Mitochondrial Self-Eating
… using conventional in vitro experimental setups. Impact on Diagnosis/Treatment of Parkinson's disease: Our current … Identifying the genes involved in this process will allow researchers to conduct a more focused search for therapeutic … Research Grant …
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Assessing the Effects of Parkin Activation in Pre-clinical Models
… of Parkinson's disease (PD). Loss of its activity leads to early-onset Parkinson's; therefore, increasing parkin … exercise. Study Design: Using a previously established research method, we will subject pre-clinical models … for cytokines, chemical signals of inflammation. Impact on Diagnosis/Treatment of Parkinson's Disease: Knowing whether …
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Evaluation of a LRRK2 Inhibitor in the Partial 6-OHDA-lesioned Model of Parkinson’s Disease
… drug. Project Description: The primary goal of this research project is to determine whether LRRK2 kinase … and/or prevent dopaminergic neurodegeneration. Relevance to Diagnosis/Treatment of Parkinson’s Disease: This project … Research Grant …
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Applying the Neuronal Alpha-synuclein Disease Integrated Staging System in Multiple System Atrophy
… years, a biological definition and staging system for PD research, called NSD-ISS, has recently been proposed. … severity and progression will be determined. Impact on Diagnosis/Treatment of Parkinson’s disease: The expected … Research Grant …
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Phase IIb Study of Intranasal Glutathione in Parkinson's Disease
… to volunteer for additional MRI measurements. Impact on Diagnosis/Treatment of Parkinson's Disease: Like dopamine, … waste and eliminating free radicals. Three decades of research suggests that the PD brain has depleted levels of … in a measurable symptomatic effect over placebo, future research efforts should focus on the capacity of (in)GSH to …