… Study Rationale: Research studies have yet to clearly explain whether alpha-synuclein oligomers -- … many possible reasons for this lack of clarity, extensive testing of new critical raw materials, such as monoclonal … and tested according to regulatory guidance for future commercialization as a companion diagnostic, i.e., a test …

… undifferentiated (and potentially tumorigenic) stem cells. To date, there is no "winning" strategy that can directly … that could then be used therapeutically. Anticipated Outcome: Our method of sorting and characterizing a few (or … population. Thus, we can use our technique to both negatively- or positively-select cells for stem-cell …

… Study Rationale:  The proteins parkin and GCase show a strong genetic link to Parkinson’s disease (PD) and are key players of … available chemical tools has hampered efforts to develop compounds that interact with these two important players in …

… Study Rationale: The proteins parkin and GCase show a strong genetic link to Parkinson’s disease (PD) and are key players of … available chemical tools has hampered efforts to develop compounds that interact with these two important players in …

… cells. They promote the transfer of molecules between cells to monitor the surrounding environment. In brain disorders … or decreasing cellular connectivity. Our aim is to target neuronal connexins particularly involved in the transfer … believe that novel designer inhibitors could be used as a complementary or alternative treatment to prevent the …

… dysfunctions. Cancer occurs when the immune system fails to safeguard, and immune therapy holds new hope for cancer … and Parkin, are among such genes. Hypothesis: We bring together a team of experts in the fields of Parkinson’s … a unique angle. The findings will help better understand common molecular mechanisms underlying Parkinson’s disease …