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Clinicopathological Features of LRRK2-related Parkinson's Disease
… aggregates that are not Lewy bodies. Impact on Diagnosis/Treatment of Parkinson's Disease: This research will characterize the pathology of LRRK2-related PD … Research Grant …
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Transglutaminase 2 Inhibitors as a Disease-Modifying Treatment for Parkinson's Disease
… This grant builds upon the research from a prior grant: Validation of a Protein, … to clump and damage the brain will be assessed. Impact on Diagnosis/Treatment of Parkinson's Disease: Identifying TG2 … Research Grant …
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Validation of the Usability of Patient-specific Midbrain Organoids for LRRK2 Drug Discovery in Parkinson’s Disease
… specific biochemical pathways in the cells. Impact on Diagnosis/Treatment of Parkinson’s disease: This research could lead to a powerful new model for testing … Research Grant …
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Establishing an LRRK2 Signaling Pathway and Assays for Patient Derived Samples
… biological techniques to achieve these goals. Relevance to Diagnosis/Treatment of Parkinson’s Disease: The successful outcome of our work will yield insight into the role of LRRK2 in Parkinson’s disease and define … MJFF Research Grant …
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The Role of Alpha-synuclein in the Pathogenesis of Parkinson’s Disease in a Pre-clinical Model
… This grant builds upon the research from a prior grant: The Role of Alpha-synuclein in … will be assayed in a time point experiment. Relevance to Diagnosis/Treatment of Parkinson’s Disease: The development … the enzyme called ALDH1A2, which quickly breaks down DOPAL into a non-toxic chemical called DOPAC. It is believe that …
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Functional Fine-mapping of LRRK2 Locus
… variants on kinase activity in immune cells. Impact on Diagnosis/Treatment of Parkinson's disease: Better … of Parkinson's. The results from this study may also help researchers design better clinical trials to test LRRK2 … Research Grant …