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New Activators of Parkin
… in parkin that impair its function are known to cause early-onset parkinsonism, an inherited form of Parkinson's … will take advantage of a new technology that empowers researchers with artificial intelligence to maximize the … of finding small-molecule activators of parkin. Impact on Diagnosis/Treatment of Parkinson's Disease: The small …
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Patient Reports on Cannabis Use in Parkinson's Disease
… drugs. We will analyze the survey results. Impact on Diagnosis/Treatment of Parkinson’s Disease: This information will enable researchers to design studies needed to define the types, … Research Grant …
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Selective mGluR3 Positive Allosteric Modulators as Neuroprotective Agents for Parkinson's Disease Supplement
… This grant builds upon the research from a prior grant: Selective mGluR3 Positive … alpha-synuclein-treated or aged) models. Impact on Diagnosis/Treatment of Parkinson’s Disease: The … Research Grant …
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Novel Nicotinic Receptor Agonist for Treating Levodopa-induced Dyskinesia
… by decreased dyskinetic activity. Importance of This Research for the Development of a New PD Therapy: … Research Grant …
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Is ATP13A2 a Lysosomal Lipid Flippase that Affects Alpha-synuclein Membrane Interactions?
… This grant builds upon the research from a prior grant: Functional Characterization of … ATP13A2 knock-out pre-clinical models. Importance of This Research for the Development of a New PD Therapy: Our … Final Outcome ATP13A2 is a protein linked to an inherited, early-onset form of Parkinson's disease (PD). ATP13A2 …
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LRRK2 Effects on Neural Differentiation
… Objective/Rationale : Several lines of research suggest that leucine-rich repeat kinase 2 (LRRK2 or … that LRRK2 plays in neural differentiation. Relevance to Diagnosis/Treatment of Parkinson’s Disease : Mutations in … Research Grant …