… This grant builds upon the research from a prior grant: Investigating signaling pathway … a clear picture of what LRRK2 is doing. Importance of This Research for the Development of a New PD Therapy: If we can … when they are starved of nutrients. Some of our previous research had revealed that LRRK2 was involved in autophagy, …

… compared to the original proposal. Importance of This Research for the Development of a New PD Therapy:  These … step in determining the utility of these animals for PD research.     … MJFF Research Grant …

… date, mutations in five genes have been identified to cause early-onset parkinsonism, which typically follows Mendelian … Currently, approximately five scientific publications from research groups worldwide are published each month claiming … risk factors and PD. For the public but also for the PD research community this wealth of information is becoming …

… possesses some deficiencies that we seek to address in this research proposal. We would like to improve the selectivity … LRRK2 as a potential therapeutic target. Relevance to Diagnosis/Treatment of Parkinson’s Disease: In order to … a key driver of some forms of Parkinson’s disease and our research aims to deliver experimental drugs that can be used …

… This grant builds upon the research from a prior grant: Development of Nurr1-RXR … be most effective means of treatment. Importance of This Research for the Development of a New PD Therapy If these … MJFF Research Grant …

… This grant builds upon the research from a prior grant: Development of Nurr1-RXR … be most effective means of treatment.  Importance of This Research for the Development of a New PD Therapy:        If … MJFF Research Grant …