… and compared against the wild type models. Relevance to Diagnosis/Treatment of Parkinson’s … models have been developed as a tool to be used in this research.  Determining if there are detrimental affects on … MJFF Research Grant …

… propose to use tools developed by MFF and available to all research groups and pharmaceuticals, namely LRRK2 KO models, … is independent of over-expressed LRRK2 enzyme. Relevance to Diagnosis/Treatment of Parkinson’s … MJFF Research Grant …

… placebo response factors on rating scales used in PD research may be a major source of measurement bias that … of these assessments for other studies. Relevance to Diagnosis/Treatment of Parkinson’s Disease: This study will … MJFF Research Grant …

… This grant builds upon the research from a prior grant: Identification of a novel … without producing unwanted side-effects. Relevance to Diagnosis/Treatment of Parkinson’s Disease: The studies to … MJFF Research Grant …

… penetrance and expressivity may be identified. Relevance to Diagnosis/Treatment of Parkinson’s Disease: James Parkinson … features of the syndrome that bears his name. An “end-diagnosis” of PD is a gross simplification of the disease … Anticipated Outcome: The project will build local research capacity, to meet the burden imposed by LRRK2 …

… for the detection of α-synuclein, which will provide early non-invasive diagnosis of Parkinson’s disease and … biomarker must be able to be imaged on MRI and must pass into the brain after injection into the patient. To … who live far from clinical centers. Further, although research has shown that accumulations of alpha-synuclein …