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The Birmingham News: UAB Part of $40 Million Parkinson's Study
August 23, 2010
… disease that has discovered ways to diagnose Alzheimer's early, using brain scans or tests of spinal fluid. Both the … biomedical science on its head. Usually, individual researchers or biomedical companies hoard their findings … willing to give up a lot of time to try to help research into this poorly understood, debilitating disease, the …
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Development of Novel, Small Molecule Compounds as PET Tracers for Synucleinopathies
… Emission Tomography) imaging agent for use in human diagnosis, clinical trials and, eventually, routine … aggregated human proteins (tau, amyloid-beta), binding to early forms of aggregated proteins, and high brain … alpha-synuclein imaging compounds that could rapidly enter into clinic. Next steps towards clinical use would involve …
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2020 Science Highlights from the American Academy of Neurology
June 9, 2020
… Design created with images courtesy of AAN.com Each year, thousands of neurologists from across the … 213 Fox Insight participants and completed online study visits with 203 people (165 with self-reported PD). They …
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Metabolic Phenotyping in PD Dopaminergic Neurons and Neuronal-glial Co-cultures Using High-throughput Single-cell Metabolomics and Lipidomics
… it is important to study them as such, contrary to previous research that has analyzed all cells together as a mixture. … cases and therefore may be useful as biomarkers of early disease. Study Design: We will use cutting-edge … differentiate cells from the PPMI cohort of PD patients into neurons and glia – key cell types in PD - and will …
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Investigating the Mechanisms of Alpha-synuclein-induced Anxiety in a Novel Preclinical Model of Parkinson’s Disease
… we know very little about what causes anxiety in PD. Research has begun to suggest that anxiety in PD may stem … will we assess brain pathology and function. Impact on Diagnosis/Treatment of Parkinson’s disease: Successful … Next Steps for Development: Recent work has suggested that early symptoms like anxiety, when paired with biomarkers …
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Tracking Eye Movements and Pupil Responses as a Diagnostic and Prognostic Biomarker in Parkinsonian Disorders
… conditions which mimic it (atypical parkinsonism) at a very early stage. Similarly, we do not have ways to track with … clips will differentiate PD and atypical parkinsonism at an early stage and allow us track and perhaps predict how the … vary among people with the same disease. Impact on Diagnosis/Treatment of Parkinson’s disease: If successful, …